Menopause & aneurysm
July 30, 2012
BRAIN aneurysms, bulges and
balloons in vessel walls have been
linked with early onset menopause,
suggesting that the premature loss
of oestrogen could be a risk factor for
aneurysm formation and
development.
The link was outlined in a new
retrospective, case-control study
that compared the gynaecologic
and medical histories of 76 cases of
consecutive postmenopausal
women who were diagnosed with
brain aneurysms and treated by a
single physician from 2009 to 2011
to 532 controls, seven controls for
each case, identified in the general
population from 1994 to 1998.
Results showed that 26.3% of the
total cases with brain aneurysms had
undergone pre-mature menopause,
defined as under age 40, as compared
with 19.2% of the control group.
When comparing across all
variables, later menopause age was
significantly associated with a lower
aneurysm incidence.
Additionally, for each categorical
increase in menopause age (40-44,
45-49, 50-54, and greater to or equal
to 55), the likelihood of developing
a brain aneurysm decreased by 21%.
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