IN 2023, the number of retractions for scientific research articles surpassed 10,000, highlighting significant issues with research integrity.
To address this, Monash University researchers have developed a pioneering framework called Research Integrity in Guidelines and Evidence synthesis (RIGID), now published in The Lancet's eClinical Medicine.
Co-lead author Prof Ben Mol said, "at least 25% of clinical trials informing guidelines may not be trustworthy".
The RIGID framework checks the integrity of clinical guidelines by providing a six-step approach to identifying concerns and improving transparency around research.
It was first applied to the International Evidence-based Guidelines for Polycystic Ovary Syndrome, involving collaboration with 39 societies and 80 experts.
This application revealed that 45% of the assessed clinical trials had moderate or high integrity risks, leading to their exclusion from the guidelines.
The above article was sent to subscribers in Pharmacy Daily's issue from 19 Jul 24
To see the full newsletter, see the embedded issue below or CLICK HERE to download Pharmacy Daily from 19 Jul 24
