RESEARCHERS at the University of South Australia have developed a new method for treating liver cancer, using 3D printed films that deliver chemotherapy drugs directly to the site of the tumour.
This technique aims to reduce the recurrence of cancer and minimise the adverse side effects typically associated with systemic chemotherapy treatments.
Embedded with the drugs 5-fluorouracil and cisplatin, these 3D films are placed precisely where the cancer has been surgically removed.
By concentrating the drugs on the necessary area, this method effectively targets residual cancer cells while limiting their spread through the body, thus reducing unwanted systemic impacts.
"By localising drug delivery, we aim to kill over 80% of targeted liver cancer cells, improving the efficacy of post-surgical treatments," said Dr Souha Youssef (pictured), the diagnostic project's lead researcher.
Liver cancer is notoriously challenging to treat effectively due to its high recurrence rates, as up to 70% in traditional scenarios involving tumour removal are followed by systemic chemotherapy.
The new method using 3D films presents a localised treatment alternative that could potentially ease the overall treatment burden on patients.
"Our 3D printed films deliver chemotherapy directly to the site involved, substantially decreasing the drug levels required in the bloodstream, which could enhance the patient's quality of life by reducing toxicity," noted Youssef.
The flexibility of 3D printing technology allows for customised treatment protocols tailored to individual patient needs, adjusting drug types, dosages, and release timelines with more precision.
Further, the films are biodegradable dissolving after treatment. JG
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