MONASH University researchers exploring what they call "dimmer switch" medicines that could help patients with obesity, diabetes and schizophrenia, have won the prestigious GSK Award for Research Excellence.
New medicines, targeting G protein-coupled receptors, can be "turned up" or "turned down" rather than "on" and "off" have been studied by Professors Arthur Christopoulos and Patrick Sexton from the Monash Institute of Pharmaceutical Sciences.
The "dimmer switch" of a protein, known as the allosteric site, offers the opportunity to tailor treatment to a patient's individual medical needs, bringing new hope for people with chronic conditions, researchers said.
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