THE Federal Health Minister Mark Butler announced the PBS listing of Australia's first combined anti-programmed cell death protein 1 (PD-1)/anti-lymphocyte-activation gene 3 (LAG-3) treatment for adult and paediatric patients aged 12 years or older with unresectable or metastatic melanoma, effective 01 Feb, at a morning press conference held at The Queen Elizabeth Hospital, Adelaide, yesterday.
Bristol Myers Squibb's Opdualag (nivolumab/relatlimab) is a fixed-dose combination of nivolumab, a PD-1 inhibitor, and relatlimab, a novel first-in-class lymphocyte-activation gene LAG-3-blocking antibody, which restores the effector function of exhausted T-cells and promotes antitumour activity.
Co-Medical Director of Melanoma Institute Australia, and 2024 NSW Australian of the Year, Prof Georgina Long, said, "inhibiting LAG-3 with relatlimab, in combination with nivolumab, gives us a new treatment to add to our toolkit against melanoma".
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