WHILE many people have successfully lost weight using glucagon-like peptide 1 receptor agonists (GLP-1 RAs), it is becoming increasingly clear that many will also regain weight after stopping them.
However, according to a new study published in eClinicalMedicine today, they may not regain all the weight that was lost.
The team reviewed studies involving more than 3,200 participants who were taking the medicines, and found that one year after stopping them, people had regained an average of 60% of the weight they lost.
After that, people's regained weight tended to plateau at around 75% of what they had lost - so they were still down around 25% from their starting weight.
"GLP-1RA cessation is associated with a predictable and decelerating pattern of weight regain, which appears to plateau below pre-treatment levels, suggesting that partial weight-loss benefit may persist long-term but is substantially attenuated," the researchers said.
"Current evidence suggests that adopting an individualised dose-tapering approach can limit weight regain, but more research is needed to develop strategies for reliable long-term weight management after GLP-1RA cessation," they concluded.
Read the research HERE. KB
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